Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson's patients and genotype-phenotype correlations

Erer, Sevda; EGELİ, ÜNAL; ZARİFOĞLU, MEHMET; Tezcan, Gulcin; ÇEÇENER, GÜLŞAH; TUNCA, BERRİN; Ak, Secil; Dernirdogen, Elif; Kenangil, Gulay; Kaleagasi, Hakan; DOĞU, OKAN; SAKA TOPÇUOĞLU, ESEN; ELİBOL, BÜLENT

doi:10.1016/j.clineuro.2016.07.005

Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson's patients and genotype-phenotype correlations

Atıf İçin Kopyala

Erer S., EGELİ Ü., ZARİFOĞLU M., Tezcan G., ÇEÇENER G., TUNCA B., ...Daha Fazla

CLINICAL NEUROLOGY AND NEUROSURGERY, cilt.148, ss.147-153, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 148
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.clineuro.2016.07.005
Dergi Adı: CLINICAL NEUROLOGY AND NEUROSURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.147-153
Anahtar Kelimeler: Parkinsonism, PARK loci, PRKN, PINK1, DJ1, SNCA, DISEASE, DJ-1, ASSOCIATION, POPULATION, EUROPE, COHORT
Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Variations in PARK genes (PRKN, PINK1, DJ-1, and SNCA) cause early-onset Parkinson's disease (EOPD) in different populations. In the current study, we aimed to evaluate the frequencies of variations in PARK genes and the effects of these variations on the phenotypes of Turkish EOPD patients.