Stimulation of lymphocyte proliferation and inhibition of nitric oxide production by aqueous Urtica dioica extract

Harput U., Saracoglu I. , Ogihara Y.

PHYTOTHERAPY RESEARCH, vol.19, no.4, pp.346-348, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1002/ptr.1686
  • Title of Journal : PHYTOTHERAPY RESEARCH
  • Page Numbers: pp.346-348
  • Keywords: Urtica dioica, Urticaceae, immunomodulation, antiinflammation, T-lymphocytes, nitric oxides, macrophages, IN-VITRO, ROOTS


The immunomodulatory and antiinflammatory activities of aqueous Urtica dioica extract were investigated for their effect on the mitogenic response of murine splenocytes and nitric oxide production by murine peritoneal macrophages in vitro. It was found that this extract stimulated the proliferation of T-lymphocytes and suppressed NO production in lipopolysaccharide - stimulated macrophages without affecting cell viability. Copyright (c) 2005 John Wiley & Sons, Ltd.