Tamoxifen citrate: a glimmer of hope for silicosis

Yoldas O., Karaca T., BİLGİN B. Ç., Yilmaz O. H., Simsek G. G., Alici I. O., ...More

JOURNAL OF SURGICAL RESEARCH, vol.193, no.1, pp.429-434, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 193 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jss.2014.08.013
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.429-434
  • Hacettepe University Affiliated: Yes


Background: Inhalation of crystalline silica nanoparticles causes pulmonary damage resulting in progressive lung fibrosis. Currently, there is no effective treatment for silicosis. Tamoxifen citrate is a selective estrogen receptor modulator, which is one of the adjuvant treatment choices for breast cancer. It is also known with its inhibitory effect on the production of transforming growth factor-beta (TGF-beta) and studied for the anti-fibrotic effect in some fibrotic diseases. The aim of the study was to determine the effect of tamoxifen citrate on the prevention of pulmonary fibrosis and the treatment of silicosis.