Akademik Veri Yönetim Sistemi
ANALYTICAL AND BIOANALYTICAL CHEMISTRY RESEARCH, cilt.9, sa.4, ss.401-409, 2022 (ESCI)
Narcotic drug use is an important problem in our country and all over the world. Hair is a valuable specimen for monitoring these long-term drug uses. For this purpose, a sensitive method was created and validated for the identification and quantification of benzoylecgonine (morphine, codeine, 6-monoacetylmorphine, heroin, tetrahydrocannabinol, amphetamine, 3,4-methylenedioxyamphetamine, buprenorphine, methamphetamine, 3,4-methylenedioxy-N-methylamphetamine, and cocaine in human hair by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The sample preparation step includes washing, standard addition, liquid-phase extraction with methanol, and solid-phase extraction steps. Analysis for substances identified from a pretreated hair took a maximum of 3.64 min. In the method, the LOD values of each substance ranged from 0.11-0.87 ng mg(-1), and the linearity was quite good (r(2) > 0.99). The concentration ranges for quantification were 0.50 and 8.00 ng mg(-1) for all substances. In addition, the intraday and interday accuracy and precision values of this method were acceptable (<12.81%) and the recovery was found to be between 93.72%-104.78% at different concentrations. The results of this study showed that the developed very fast and reliable LC-MS/MS method is suitable for use as a validated method in the analysis of illicit drugs simultaneously in hair.