Broad IgG repertoire in patients with chronic rhinosinusitis with nasal polyps regulates proinflammatory IgE responses

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Shamji M. H., Thomsen I., Layhadi J. A., Kappen J., Holtappels G., Sahiner Ü. M., ...Daha Fazla

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.143, sa.6, ss.2086-2096, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 143 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jaci.2019.02.001
  • Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2086-2096
  • Anahtar Kelimeler: IgG, antibody repertoire, IgE, chronic rhinosinusitis, nasal polyps, allergic rhinitis, STAPHYLOCOCCUS-AUREUS ENTEROTOXINS, CLASS SWITCH RECOMBINATION, FLOW-CYTOMETRY, T-CELLS, ALLERGEN, SERUM, IMMUNOTHERAPY, ACTIVATION, EXPRESSION, ANTIBODIES
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE idiotypes. Although tissue IgE concentrations can be in the range of several thousand kilounits per liter, the regulatory mechanisms by which IgE-mediated inflammation is controlled in patients with nasal polyps are not well understood.