Broad IgG repertoire in patients with chronic rhinosinusitis with nasal polyps regulates proinflammatory IgE responses


Shamji M. H. , Thomsen I., Layhadi J. A. , Kappen J., Holtappels G., Sahiner U., ...Daha Fazla

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.143, ss.2086-2096, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 143 Konu: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jaci.2019.02.001
  • Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Sayfa Sayıları: ss.2086-2096

Özet

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE idiotypes. Although tissue IgE concentrations can be in the range of several thousand kilounits per liter, the regulatory mechanisms by which IgE-mediated inflammation is controlled in patients with nasal polyps are not well understood.