Broad IgG repertoire in patients with chronic rhinosinusitis with nasal polyps regulates proinflammatory IgE responses

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Shamji M. H., Thomsen I., Layhadi J. A., Kappen J., Holtappels G., Sahiner Ü. M., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.143, no.6, pp.2086-2096, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 143 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jaci.2019.02.001
  • Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2086-2096
  • Keywords: IgG, antibody repertoire, IgE, chronic rhinosinusitis, nasal polyps, allergic rhinitis, STAPHYLOCOCCUS-AUREUS ENTEROTOXINS, CLASS SWITCH RECOMBINATION, FLOW-CYTOMETRY, T-CELLS, ALLERGEN, SERUM, IMMUNOTHERAPY, ACTIVATION, EXPRESSION, ANTIBODIES
  • Hacettepe University Affiliated: Yes

Abstract

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE idiotypes. Although tissue IgE concentrations can be in the range of several thousand kilounits per liter, the regulatory mechanisms by which IgE-mediated inflammation is controlled in patients with nasal polyps are not well understood.