Children with lymphoma presenting with hemophagocytic lymphohistiocytosis

Aksu T., Bayhan T., Gülhan B., Çakmakcı S., Oğuz A. S., Yaralı N., ...Daha Fazla

The Turkish journal of pediatrics, cilt.62, sa.2, ss.284-288, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.24953/turkjped.2020.02.016
  • Dergi Adı: The Turkish journal of pediatrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.284-288
  • Anahtar Kelimeler: anaplastic large cell lymphoma, hemophagocytic lymphohistiocytosis, Hodgkin lymphoma
  • Hacettepe Üniversitesi Adresli: Evet

Özet

BACKGROUND: < 7b > Hemophagocytic lymphohistiocytosis (HLH) may precede malignancy, in particular lymphomas and leukemias. However, the causative factors, appropriate treatment and the prognosis of this association is not established. CASE: Herein, we present two patients, one with nodular sclerosing Hodgkin lymphoma (HL) and concomitant Epstein-Barr virus (EBV) infection, and the other with anaplastic large cell lymphoma (ALCL), presented as malignancy associated HLH. CONCLUSION: In our patients, malignancy directed therapy was sufficient to treat HLH symptoms both at presentation and at recurrence in the second patient.