Experimental In Vivo Toxicity Models for Alcohol Toxicity

YOLADI F. B., Burmaoglu E., Palabiyik-Yucelik S. S.

EURASIAN JOURNAL OF MEDICINE, vol.55, 2023 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 55
  • Publication Date: 2023
  • Doi Number: 10.5152/eurasianjmed.2023.23345
  • Journal Name: EURASIAN JOURNAL OF MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Hacettepe University Affiliated: No

Abstract

Alcohol consumption poses a significant risk for the development of chronic illnesses, one of the leading causes of "preventable" disease and death worldwide. Harmful consumption of alcohol is thought to result in approximately 2.5-3 million deaths each year, the majority of which are caused by alcohol -related liver diseases. Hepatocellular carcinoma, cirrhosis, fibrosis, steatosis, and steatohepatitis are among the liver illnesses caused by alcohol. The mechanisms behind human diseases are often mimicked and understood through the use of animal models. Rodents are the ideal animals to study alcohol -related liver diseases. In these experimental models using rodents, the ethanol ratio, method of administration, and diet to be applied vary. Within the scope of this review, it is aimed at providing information about the experimental models used today for alcohol toxicity and the advantages and disadvantages of these models.