Effect of permeability enhancers on paracellular permeability of acyclovir


Ates M., KAYNAK M. S. , ŞAHİN S.

JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.68, no.6, pp.781-790, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1111/jphp.12551
  • Title of Journal : JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Page Numbers: pp.781-790

Abstract

Objectives According to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir.