Iridoid and phenylethyl glycosides from Globularia sintenisii

Kirmizibekmez H., Calis I., Piacente S., Pizza C.

HELVETICA CHIMICA ACTA, vol.87, no.5, pp.1172-1179, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 87 Issue: 5
  • Publication Date: 2004
  • Doi Number: 10.1002/hlca.200490107
  • Journal Name: HELVETICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1172-1179
  • Hacettepe University Affiliated: Yes

Abstract

A new iridoid glycoside, sintenoside (1) and two new phenylethyl glycosides, globusintenoside (-2-(3,4-dihydroxyphenyl)ethyl-O-6-O-feruloyl-beta-D-glucopyranosyl-(1 - 4)-alpha-L-rhamnopyranosyl-(1-->3)-4-O-caffeoyl-beta-D-glucopyranoside; 2) and 3'"-O-methylcrenatoside (=1,2-O-[2-(3.4-dihydroxyphenyl)ethan-1,2-diyl]-3-O-alpha-L-4-O-feruloyl-rhamnopyransyl-beta-D-glucopyranose; 3) were isolated from the underground parts of Globularia sintenisii, along with three known iridoid glycosides, lytanthosalin, globularin, catalpol, and six known phenylethyl glycosides, verbascoside, isoverbascoside, leucoscepthoside A, plantainoside C, martynoside, and isocrenatoside. The structure elucidation of the isolated compounds was performed by spectroscopic methods (MS and 1D and 2D NMR).