Increasing carbapenem resistance due to the clonal dissemination of oxacillinase (OXA-23 and OXA-58)-producing Acinetobacter baumannii: report from the Turkish SENTRY Program sites

GÜR D., Korten V., ÜNAL S., DESHPANDE L. M., CASTANHEIRA M.

JOURNAL OF MEDICAL MICROBIOLOGY, vol.57, no.12, pp.1529-1532, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 12
  • Publication Date: 2008
  • Doi Number: 10.1099/jmm.0.2008/002469-0
  • Journal Name: JOURNAL OF MEDICAL MICROBIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1529-1532
  • Hacettepe University Affiliated: Yes

Abstract

A significant increase in carbapenem-resistance rates among Acinetobacter baumannii isolates collected in two Turkish medical centres was detected in the 2000-2006 period (20-60%) by the SENTRY Antimicrobial Surveillance Program. Carbapenem-resistant strains from 2006 were evaluated for the presence of encoding genes and epidemic clonality. OXA-58-like and OXA-23-like carbapenemase-producing strains were detected in both medical institutions. Seventeen out of 18 strains from Ankara were positive for bla(OXA-58) primers and belonged to the same clone, whilst 26 isolates (25 from Istanbul and one from Ankara) harboured bla(OXA-23)-like genes and showed identical or similar PFGE patterns. Isolates producing OXA-23-like carbapenemases were more resistant than OXA-58-like carbapenemase producers to non-carbapenem antimicrobial agents. Carbapenem resistance in these institutions was observed to be largely driven by the dissemination of clones producing OXA-type carbapenemases.