Molecularly Imprinted Based Sensors for Detection of Allergens

Akgönüllü S., Yavuz Alagöz H., Denizli A.

in: Molecular Imprinting for Nanosensors and Other Sensing Applications, Prof. Dr. Adil DENIZLi, Editor, Elsevier Science, Oxford/Amsterdam , Amsterdam, pp.309-334, 2021

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2021
  • Publisher: Elsevier Science, Oxford/Amsterdam 
  • City: Amsterdam
  • Page Numbers: pp.309-334
  • Editors: Prof. Dr. Adil DENIZLi, Editor
  • Hacettepe University Affiliated: Yes


Allergy is a widespread disease effective 10%–20% of the general population all around the world. Allergies are chronic illnesses caused by the exposure of the respiratory system to dust or pollen, the skin to chemical materials, or the digestion system to particular foods. Immunoglobulin E (IgE) antibody plays a very important role in the development of allergies in humans. The high level of total IgE in human serum reflects the presence of allergic conditions. Test kits for commercially available serum IgE measurements are based on conventional immunoassay techniques. These techniques include time-consuming procedures, expensive instruments, and hazardous labels. Currently, molecularly imprinted polymer-based sensors are utilized as an alternative artificial receptor. MIP-based sensor systems for biological applications have been widely utilized in works on biomolecular interactions, with the change in sensor signals. Herein, the development of rapid, easy-to-use and cost-effective allergen detection methods based on mass sensitive, optic, electrochemical, and nanomaterials based sensors have been reported. Finally, we present sensor systems were investigated with a molecular imprinting technique for the detection of allergens as a marker of various allergies.