An expanded evaluation of protein function prediction methods shows an improvement in accuracy

Jiang Y., Oron T. R., Clark W. T., Bankapur A. R., D'Andrea D., Lepore R., ...More

GENOME BIOLOGY, vol.17, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2016
  • Doi Number: 10.1186/s13059-016-1037-6
  • Journal Name: GENOME BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Protein function prediction, Disease gene prioritization, DISINTEGRIN, ONTOLOGY, ADAM
  • Hacettepe University Affiliated: No

Abstract

Background: A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins, their relatively low throughput and restricted purview have led to an increasing role for computational function prediction. However, assessing methods for protein function prediction and tracking progress in the field remain challenging.