Recipient-derived hepatocytes in sex-mismatched liver allografts after liver transplantation: Early versus late transplant biopsies

Idilman R., Erden E., Kuzu I., Ersoz S., Karasu A. Z., Karayalcin K., ...More

TRANSPLANTATION, vol.78, no.11, pp.1647-1652, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 11
  • Publication Date: 2004
  • Doi Number: 10.1097/01.tp.0000144055.78462.4f
  • Journal Name: TRANSPLANTATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1647-1652
  • Keywords: stem cells, liver transplantation, repopulation, hepatocyte, BONE-MARROW, CELLS, MICROCHIMERISM, FUSION
  • Hacettepe University Affiliated: No

Abstract

Background. The presence of microchimerism in transplanted tissues is well defined; however, the timeframe of appearance and disappearance of engraftment in liver allograft is unknown. The aims of this study were to analyze for the presence of "recipient-derived cells" in sex-mismatched individuals after liver transplantation, comparing the frequency of "recipient-derived cell repopulation" in early versus late transplant biopsies and to evaluate the relationship between "recipient-derived cell repopulation" and the severity of graft injury.