Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography

Tang J. , Erdener S. E. , Li B., Fu B., Sakadzic S., Carp S. A. , ...Daha Fazla

Conference on Neural Imaging and Sensing, San-Francisco, Kostarika, 29 - 30 Ocak 2018, cilt.10481 identifier identifier

  • Cilt numarası: 10481
  • Doi Numarası: 10.1117/12.2290345
  • Basıldığı Şehir: San-Francisco
  • Basıldığı Ülke: Kostarika


Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained 3D volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements indicate a blunted laminar flow profile, and the degree of blunting decreases with increasing vessel diameter. The measured shear-induced diffusion coefficient was proportional to the flow shear rate with a magnitude of similar to 0.1 to 0.5 x 10(-6) mm(2). These results provide important experimental support for the recent theoretical explanation for why DCS is dominantly sensitive to RBC diffusive motion.