Oral multiple w/o/w emulsion formulation of a peptide salmon calcitonin: in vitro in vivo evaluation


Dogru S., Calis S. , Oner F.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, cilt.25, ss.435-443, 2000 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 25 Konu: 6
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1046/j.1365-2710.2000.00306.x
  • Dergi Adı: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
  • Sayfa Sayıları: ss.435-443

Özet

Background: Salmon calcitonin (sCT) is a polypeptide hormone consisting of 32 amino acid residues (MW approx. 3400 Da), which can be used successfully for the treatment of osteoporosis, Paget's disease and hypercalcaemia. Only nasal and parenteral preparations of sCT are currently available, and as injections are poorly accepted by patients, nonparenteral preparations for oral, rectal and nasal administration are highly desirable. However, oral sCT is poorly bioavailable, being susceptible to enzymatic degradation in the gastrointestinal tract.