Oral multiple w/o/w emulsion formulation of a peptide salmon calcitonin: in vitro in vivo evaluation
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, cilt.25, sa.6, ss.435-443, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 6
- Basım Tarihi: 2000
- Doi Numarası: 10.1046/j.1365-2710.2000.00306.x
- Dergi Adı: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.435-443
- Hacettepe Üniversitesi Adresli: Evet
Özet
Background: Salmon calcitonin (sCT) is a polypeptide hormone consisting of 32 amino acid residues (MW approx. 3400 Da), which can be used successfully for the treatment of osteoporosis, Paget's disease and hypercalcaemia. Only nasal and parenteral preparations of sCT are currently available, and as injections are poorly accepted by patients, nonparenteral preparations for oral, rectal and nasal administration are highly desirable. However, oral sCT is poorly bioavailable, being susceptible to enzymatic degradation in the gastrointestinal tract.