Vincristine-Induced Unilateral Ptosis in a Child

Gursel O., Sari E., Altun D., Atay A. A. , Akin R.

PEDIATRIC NEUROLOGY, cilt.41, sa.6, ss.461-463, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Konu: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.pediatrneurol.2009.07.005
  • Sayfa Sayıları: ss.461-463


Vincristine is a vinca alkaloid used in combination with other agents in the treatment of solid tumors, lymphoma, and leukemia, as well as for idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia. A dose-limiting complication of vinca alkaloids is neurotoxicity. Vincristine is the oldest and also the most neurotoxic agent in this group. Described here is the case of a 4-year-old girl with unilateral palpebral ptosis. She has been diagnosed with precursor B-cell acute lymphoblastic leukemia. Ptosis was noted on the 45th day of therapy, and the last vincristine was administered on the 28th day of protocol 1. Vincristine-induced unilateral palpebral ptosis is a novel finding. Experience with this case suggests conservative treatment, with periodic examination, especially if ptosis is mild. (C) 2009 by Elsevier Inc. All rights reserved.