Are platelet indices promising ratios for predicting pediatric septic shock prognosis?

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Celegen M., KESİCİ S., Yavuz S., Celegen K., BAYRAKCİ B.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.123, no.6, pp.444-448, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.4149/bll_2022_069
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.444-448
  • Keywords: septic shock, mortality, platelet indices, thrombocytopenia, children, VOLUME/PLATELET COUNT RATIO, DISTRIBUTION WIDTH, VOLUME, MORTALITY, SEPSIS, THROMBOCYTOPENIA, ASSOCIATION, CHILDREN, MARKER
  • Hacettepe University Affiliated: Yes


OBJECTIVES: The aim of the present study was to determine the prognostic value of thrombocytopenia, platelet indices (MPV/PLT and PDW/PLT) in children with septic shock. BACKGROUND: Septic shock is one of the major causes of mortality among children worldwide. METHODS: A retrospective analysis was made of children admitted to the pediatric intensive care unit between November 2010 and December 2019. Two hundred four children were included; they were diagnosed with septic shock according to the international pediatric sepsis consensus conference criteria. The MPV/platelet ratio and PDW/platelet ratios were estimated as the MPV and PDW values divided by the platelet count on the fi rst three days of hospitalization. The clinical outcome was 28-day mortality. RESULTS: MPV/PLT and PDW/PLT ratios were found to be signifi cantly higher in the non-survivors than survivor (p??? 0.001). In the multivariate logistic regression analysis, higher MPV/platelet ratios at 72h (OR: 7.41; 95% CI: 1.25???43.7; p= 0.027) and PDW/platelet ratios at 72h (OR: 2.9; 95% CI: 1.13???7.50; p= 0.027) were signifi cant risk factors for mortality. CONCLUSIONS: Platelet indices are useful laboratory parameters in septic shock. MPV/PLT and PDW/PLT ratios can be promising reliable markers for 28-day mortality in children with septic shock (Tab. 4, Fig. 1, Ref. 29). Text in PDF