Peptide Based Vaccine Strategies

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AYDIN S., VARAN G., ÜNAL S.

FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, vol.27, no.2, pp.189-195, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 27 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.5578/flora.20229801
  • Journal Name: FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.189-195
  • Keywords: Synthetic peptide vaccine, Multiepitope approach, EPITOPES, ADJUVANT, PREDICTION
  • Hacettepe University Affiliated: Yes

Abstract

Synthetic peptides are easy tool to investigate binding capacities, proteolytic activities and immunogenicity properties of proteins. They enable the development of vaccine candidates that can create a specific protective immune response by stimulating both cellular and humoral immunity with the B and T cell epitopes determined based on the nucleotide/amino acid sequence data of the pathogens. Although they are safe, biocompatible, and cost-effective, they have low immunogenicity capacities and are susceptible to enzymatic degradation. Effective and stable vaccines can be developed by increasing the immunogenicity capacities of synthetic peptides with a multiepitope approach and an appropriate adjuvant/carrier system.