Peptide Based Vaccine Strategies

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AYDIN S., VARAN G., ÜNAL S.

FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, cilt.27, sa.2, ss.189-195, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5578/flora.20229801
  • Dergi Adı: FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.189-195
  • Anahtar Kelimeler: Synthetic peptide vaccine, Multiepitope approach, EPITOPES, ADJUVANT, PREDICTION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Synthetic peptides are easy tool to investigate binding capacities, proteolytic activities and immunogenicity properties of proteins. They enable the development of vaccine candidates that can create a specific protective immune response by stimulating both cellular and humoral immunity with the B and T cell epitopes determined based on the nucleotide/amino acid sequence data of the pathogens. Although they are safe, biocompatible, and cost-effective, they have low immunogenicity capacities and are susceptible to enzymatic degradation. Effective and stable vaccines can be developed by increasing the immunogenicity capacities of synthetic peptides with a multiepitope approach and an appropriate adjuvant/carrier system.