Peptide Based Vaccine Strategies
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, vol.27, no.2, pp.189-195, 2022 (ESCI, TRDizin)
- Publication Type: Article / Review
- Volume: 27 Issue: 2
- Publication Date: 2022
- Doi Number: 10.5578/flora.20229801
- Journal Name: FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
- Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Page Numbers: pp.189-195
- Keywords: Synthetic peptide vaccine, Multiepitope approach, EPITOPES, ADJUVANT, PREDICTION
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: Yes
Abstract
Synthetic peptides are easy tool to investigate binding capacities, proteolytic activities and immunogenicity properties of proteins. They enable the development of vaccine candidates that can create a specific protective immune response by stimulating both cellular and humoral immunity with the B and T cell epitopes determined based on the nucleotide/amino acid sequence data of the pathogens. Although they are safe, biocompatible, and cost-effective, they have low immunogenicity capacities and are susceptible to enzymatic degradation. Effective and stable vaccines can be developed by increasing the immunogenicity capacities of synthetic peptides with a multiepitope approach and an appropriate adjuvant/carrier system.