Peptide Based Vaccine Strategies

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AYDIN S., VARAN G., ÜNAL S.

FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, cilt.27, sa.2, ss.189-195, 2022 (ESCI, TRDizin)

• Yayın Türü: Makale / Derleme
• Cilt numarası: 27 Sayı: 2
• Basım Tarihi: 2022
• Doi Numarası: 10.5578/flora.20229801
• Dergi Adı: FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.189-195
• Anahtar Kelimeler: Synthetic peptide vaccine, Multiepitope approach, EPITOPES, ADJUVANT, PREDICTION
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Hacettepe Üniversitesi Adresli: Evet

Özet

Synthetic peptides are easy tool to investigate binding capacities, proteolytic activities and immunogenicity properties of proteins. They enable the development of vaccine candidates that can create a specific protective immune response by stimulating both cellular and humoral immunity with the B and T cell epitopes determined based on the nucleotide/amino acid sequence data of the pathogens. Although they are safe, biocompatible, and cost-effective, they have low immunogenicity capacities and are susceptible to enzymatic degradation. Effective and stable vaccines can be developed by increasing the immunogenicity capacities of synthetic peptides with a multiepitope approach and an appropriate adjuvant/carrier system.