Purpose: The goal of this study was to assess the effects of three different physiotherapy approaches on rehabilitation of amputees with thromboangiitis obliterans. Material and methods: This study was conducted on 34 lower-limb amputees. Amputees were divided into three groups after their prosthetic fitting. Connective tissue manipulation (CTM) and interferential therapy (IT) were applied to the first and second groups besides exercise programs and prosthetic training. The third group consisted of amputees who had received exercises and prosthetic training. Sensory state, skin temperature, Intermittent Claudicatio (IC) distance and time, gait parameters and ambulatory activities were evaluated in the pre and post treatment period. Results: Important differences were found between pre and post treatment values in all groups (p<0.05). When the groups were evaluated for the skin temperature of both extremities, no difference was found between Group 1 and 2, and between Group 1 and 3 (p>0.05), however a statistical difference between Group 2 and 3 was observed in the posttreatment values (p<0.05). When the groups were compared according to IC treatment results, in both distance and time, there were statistically important differences between Group 1 and 2, and Group 2 and 3 (p>0.05), but no differences were detected between group I and group III (p>0.05). Weight bearing and gait data showed no differences among the groups (p>0.05). Conclusion: Consequently, it can be said that CTM, IT and exercise programs were all effective in the rehabilitation of amputees with thromboangiitis obliterans.