Evaluation of protective effects of the alpha lipoic acid after spinal cord injury: An animal study

Tas, Nilufer; BAKAR, BÜLENT; Kasimcan, Mustafa; GAZYAĞCI, SERKAL; Ayva, Sebnem; Kilinc, Kamer; Evliyaoglu, Cetin

doi:10.1016/j.injury.2010.05.027

Evaluation of protective effects of the alpha lipoic acid after spinal cord injury: An animal study

Tas N., BAKAR B., Kasimcan M. O., GAZYAĞCI S., Ayva S. K., Kilinc K., ...Daha Fazla

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, cilt.41, sa.10, ss.1068-1074, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 41 Sayı: 10
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.injury.2010.05.027
Dergi Adı: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1068-1074
Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: Many of the hypotheses have been suggested to explain the mechanism of the secondary effects of traumatic spinal cord injury (TSCI) as follows: ischaemia/reperfusion disability theory, free radicals theory, exitotoxicity theory, immunological destruction theory, apoptosis theory. Recently, free radicals, lipid peroxidation reactions and apoptosis theories have been much more accepted than others. In this study, possible protective effects of the alpha lipoic acid were evaluated in the traumatic spinal cord of rats.