Abietic acid inhibits lipoxygenase activity

Ulusu N., Ercil D., Sakar M., Tezcan E.

PHYTOTHERAPY RESEARCH, cilt.16, sa.1, ss.88-90, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1002/ptr.983
  • Dergi Adı: PHYTOTHERAPY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.88-90
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC50 of 29.5 +/- 1.29 muM was determined. Since the lipoxygenase pathway leads to the blosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions. Copyright (C) 2002 John Wiley Sons, Ltd.