Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients

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Topcu D. B., Tugcu G., ER B., Polat S. E., Hizal M., Yalcin E. E., ...Daha Fazla

Inflammation, cilt.45, sa.2, ss.627-638, 2022 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s10753-021-01572-2
  • Dergi Adı: Inflammation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.627-638
  • Anahtar Kelimeler: Cystic fibrosis, YKL-40, Chitotriosidase activity, Exacerbation, Inflammation, Respiratory function test, PROTEIN YKL-40, INFLAMMATION, DISEASE, STANDARDIZATION, EXACERBATION, SPIROMETRY, BIOMARKER, MARKER, ASTHMA
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Hacettepe Üniversitesi Adresli: Evet

Özet

© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.We investigated plasma YKL-40 levels and chitotriosidase (CHIT1) activity in patients with cystic fibrosis (CF) lung disease and evaluated clinically relevant factors that may affect their levels. Plasma samples were obtained from pediatric (n = 19) and adult patients (n = 15) during exacerbation, discharge, and stable period of the disease. YKL-40 levels and chitotriosidase activity were measured by enzyme-linked immunosorbent assay and fluorometric assay, respectively. Data were compared with healthy children and adults of similar age. YKL-40 levels of pediatric and adult CF patients at all periods were significantly higher than controls (p < 0.001 and p < 0.05). CHIT1 activities of adult patients at all periods were significantly higher compared to controls (p < 0.05). On the other hand, CHIT1 activities of pediatric CF patients were similar with controls. YKL-40 levels of exacerbation period of adult CF patients were negatively correlated with forced vital capacity (FVC) (r = − 0.800, p = 0.014) and forced expiratory volume in 1 s (FEV1) (r = − 0.735, p = 0.008). YKL-40 levels in the exacerbation period of pediatric CF patients were negatively correlated with FVC (r = − 0.697, p = 0.0082) and FEV1 (r = − 0.720, p = 0.006). CHIT1 activity may be a valuable marker of chronic inflammation in adult CF patients who suffer from CF for a longer period compared to pediatric patients. Increased YKL-40 levels in both pediatric and adult patients compared to controls may point to a role in between CF pathology.