Effects of caffeic acid phenethyl ester on thioacetamide-induced hepatic encephalopathy in rats

FADILLIOĞLU, ERSİN; Gursul, Cebrail; Iraz, Mustafa

doi:10.1016/j.pnpbp.2010.07.034

Effects of caffeic acid phenethyl ester on thioacetamide-induced hepatic encephalopathy in rats

Atıf İçin Kopyala

FADILLIOĞLU E., Gursul C., Iraz M.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, cilt.34, sa.8, ss.1440-1445, 2010 (SCI-Expanded)

Yayın Türü: Makale / Derleme
Cilt numarası: 34 Sayı: 8
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.pnpbp.2010.07.034
Dergi Adı: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1440-1445
Hacettepe Üniversitesi Adresli: Evet

Özet

Hepatic encephalopathy (HE) is a major neurological complication secondary to severe liver failure. The aim of the present study was to examine the possible neuroprotective effects of caffeic acid phenethyl ester (CAPE) with or without laxative treatment against thioacetamide-induced HE by investigating behavioral and motor activities in rats as well as blood ammonia level and oxidant-antioxidant parameters of cortex, brain stem and cerebellum.