ERS International Congress 2019, Madrid, Spain, 28 September - 02 October 2019
urpose: Frailty defines a clinical syndrome characterized by multiple system effects leading to decreased functional reserve and increased sensitivity to mortality or mortality following minor stress events. Inflammation, lack of physical activity, reduced exercise efficiency and maximum oxygen uptake may contribute to the development of fragility in patients with chronic obstructive pulmonary disease (COPD). We aimed to compare exercise capacity, physical activity level, and balance in patients with and without frail COPD.
Methods: Thirty-one clinically stable COPD patients (11 frail [3F,8M,mean age=65.55±5.92 years]; 20 non-frail [1F,19M,mean age=66.10±5.66 years]) were included in study. Frailty was identified by presence of three or more of the following criteria unintentional weight loss, weakness (grip strength), self-reported exhaustion, slow walking speed (4-m walk test) and low physical activity (International Physical Activity Questionnaire-Short Form).Exercise capacity was assessed using the 6-min walk test (6MWT). Physical activity level was assessed using a triaxial armband monitor. The functional reach test was used to evaluate.
Results: The 6MWT distance of frail COPD patients was significantly lower than non-frail patients (p<0.001). The balance,daily average active energy expenditure, number of steps and walking distances of frail patients were significantly lower than non-frail patients (p<0.05).
Conclusion: The presence of fragility in COPD patients contribute to exercise intolerance, physical inactivity as well as impaired balance and vice versa. The development of specific treatment strategies seems to be necessary according to presence of frailty.