Akademik Veri Yönetim Sistemi
Fabad Journal of Pharmaceutical Sciences, cilt.41, sa.1, ss.39-49, 2016 (Scopus)
Phenolic compounds, one of the most commonly occurring groups of phytochemicals, play an important role in the growth and reproduction of plants, providing protection against pathogens and predators, also contributing towards the colour and sensory characteristics of fruits and vegetables. In humans, it is also suggested to have antioxidant, anti-inflammatory, antimicrobial, anticancer, and cardioprotective effects. Sinapic acid is a small naturally occurring hydroxycinnamic acid derivative. It is a phenolic compound and a member of the phenylpropanoid family which are assumed as therapeutically beneficial and generally non-toxic. Sinapic acid is widespread in the plant kingdom (fruits, vegetables, cereal grains, oilseed crops, some spices and medicinal plants) and in human diet. Derivatives of sinapic acid are characteristic compounds in the Brassicaceae family. Sinapic acid shows antioxidant, antimicrobial, anti-inflammatory, anticancer, and anxiolytic activities. Mainly due to their antioxidative activities, these compounds have been suggested for potential use in food processing, cosmetics, and pharmaceutical industry. In this review, the pharmacological effect, toxicity and safety profile of sinapic acid were assessed.