IL-8 contributes to functional diversity of tumor-infiltrating neutrophils: A new target for cancer immunotherapy

Tavukcuoglu E., ESENDAĞLI G.

DEVELOPMENTAL CELL, no.3, pp.339-341, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2025
  • Doi Number: 10.1016/j.devcel.2025.01.003
  • Journal Name: DEVELOPMENTAL CELL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE, Nature Index
  • Page Numbers: pp.339-341
  • Hacettepe University Affiliated: Yes

Abstract

In this issue of Developmental Cell, Tang et al. identify CD74high neutrophils as a subpopulation promoted by IL-8 in the tumor microenvironment of non-small lung cancer (NSCLC). These CD74high neutrophils support anti-tumor T cell responses and enhance the efficacy of anti-PD-1 immunotherapy and targeted therapy in NSCLC.