Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown pathogenesis. In this abstract we report a 34 years old female SLE case with cavitary pulmonary lesion as the pulmonary manifestation. In literature, SLE with cavitary pulmonary lesion is reported very rarely and thought to be due to infection or pulmonary embolism. Our case had no signs of infection and no finding of pulmonary embolism, the lesion resolved by steroid therapy and without antibiotic administration. In conclusion SLE should be thought in differential diagnosis of cavitary pulmonary lesions.