Leukemic stem cells shall be searched in the bone marrow before "tyrosine kinase inhibitor-discontinuation" in chronic myeloid leukemia

İLHAN O., Narli Ozdemir Z., DALVA K., ARSLAN A., Okay Ozgeyik M., Ipek S., ...Daha Fazla

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, cilt.43, sa.5, ss.1110-1116, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/ijlh.13528
  • Dergi Adı: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1110-1116
  • Anahtar Kelimeler: CML, flow cytometry, stem cell
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background Leukemic stem cells (LSCs) of chronic myeloid leukemia (CML), persisting in the bone marrow (BM) niche, could be responsible for the relapses within the patients of whom the treatment-free remission (TFR) had been attempted. We assessed the presence of the CML LSCs in the peripheral blood (PB) and concurrently in the BM in the patients with chronic-phase CML (CP CML).