Superconducting nanowire single-photon sensing of cerebral blood flow.

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Ozana N., Zavriyev A. I., Mazumder D., Robinson M., Kaya K., Blackwell M., ...More

Neurophotonics, vol.8, pp.35006, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8
  • Publication Date: 2021
  • Doi Number: 10.1117/1.nph.8.3.035006
  • Journal Name: Neurophotonics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Compendex, EMBASE, INSPEC, Directory of Open Access Journals
  • Page Numbers: pp.35006
  • Keywords: superconducting nanowire detectors, diffuse correlation spectroscopy, cerebral blood flow, pulsatile blood flow, DIFFUSE CORRELATION SPECTROSCOPY, OPTICAL-PROPERTIES, WAVE SPECTROSCOPY
  • Hacettepe University Affiliated: Yes

Abstract

Significance: The ability of diffuse correlation spectroscopy (DCS) to measure cerebral blood flow (CBF) in humans is hindered by the low signal-to-noise ratio (SNR) of the method. This limits the high acquisition rates needed to resolve dynamic flow changes and to optimally filter out large pulsatile oscillations and prevents the use of large source-detector separations (>= 3 cm), which are needed to achieve adequate brain sensitivity in most adult subjects.