Witteveen-Kolk Syndrome With Cleft Palate: A Case Report and Review of the Literature

Boynuyogun E., Irmak Y., KARA M., Ozgur F.

CLEFT PALATE CRANIOFACIAL JOURNAL, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2025
  • Doi Number: 10.1177/10556656251314260
  • Journal Name: CLEFT PALATE CRANIOFACIAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, Educational research abstracts (ERA), EMBASE, Linguistics & Language Behavior Abstracts, MEDLINE, Veterinary Science Database
  • Hacettepe University Affiliated: Yes

Abstract

Witteveen-Kolk syndrome (WITKOS) is an exceptionally uncommon genetic and neurodevelopmental disorder, characterized by developmental delay, mild intellectual disability, and craniofacial dysmorphic features. Although cleft palate (CP) has rarely been reported in WITKOS, CP in this condition has not been assessed in detail. Here, we present a case of WITKOS with a CP. The patient was a 2-year-old male and he was referred to our clinic with CP and dysmorphic clinical findings. Screening for CP should be considered when a diagnosis of WITKOS is made. CP repair can be performed successfully after neurodevelopmental maturation is complete.