Successful treatment of myelodysplastic syndrome-induced pyoderma gangrenosum


Koca E., Duman A. E. , Cetiner D., Buyukasik Y., Haznedaroglu I. C. , ÜNER A. , ...Daha Fazla

NETHERLANDS JOURNAL OF MEDICINE, cilt.64, ss.422-424, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 64 Konu: 11
  • Basım Tarihi: 2006
  • Dergi Adı: NETHERLANDS JOURNAL OF MEDICINE
  • Sayfa Sayıları: ss.422-424

Özet

We report successful treatment of a refractory myelodysplastic syndrome-associated pyoderma gangrenosum with the combination of thalidomide and interferon-alpha 2a in a single patient. A non-healing wound developed on a 40-year-old woman's left thumb after minor trauma. Massive ulcerovegetative lesions developed after reconstruction surgery. Histopathological examination of the bone marrow and cytogenetic studies revealed an atypical myeloproliferative/myelodysplastic syndrome. The skin lesions resolved dramatically after two months of thalidomide and interferon-a2a combination therapy and the haematological status improved.