Successful treatment of myelodysplastic syndrome-induced pyoderma gangrenosum

Koca E., Duman A. E., Cetiner D., Buyukasik Y., Haznedaroglu I. C., ÜNER A., ...More

NETHERLANDS JOURNAL OF MEDICINE, vol.64, no.11, pp.422-424, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 11
  • Publication Date: 2006
  • Journal Name: NETHERLANDS JOURNAL OF MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.422-424
  • Hacettepe University Affiliated: Yes

Abstract

We report successful treatment of a refractory myelodysplastic syndrome-associated pyoderma gangrenosum with the combination of thalidomide and interferon-alpha 2a in a single patient. A non-healing wound developed on a 40-year-old woman's left thumb after minor trauma. Massive ulcerovegetative lesions developed after reconstruction surgery. Histopathological examination of the bone marrow and cytogenetic studies revealed an atypical myeloproliferative/myelodysplastic syndrome. The skin lesions resolved dramatically after two months of thalidomide and interferon-a2a combination therapy and the haematological status improved.