Successful treatment of myelodysplastic syndrome-induced pyoderma gangrenosum

Koca, E.; Duman, A.; Cetiner, D.; Buyukasik, Y.; Haznedaroglu, I.; ÜNER, AYŞEGÜL; Demirhan, B.; Kerimoglu, U.; Barista, İBRAHİM; Calguneri, M.; Ozcebe, O.

Successful treatment of myelodysplastic syndrome-induced pyoderma gangrenosum

Koca E., Duman A. E., Cetiner D., Buyukasik Y., Haznedaroglu I. C., ÜNER A., ...Daha Fazla

NETHERLANDS JOURNAL OF MEDICINE, cilt.64, sa.11, ss.422-424, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 64 Sayı: 11
Basım Tarihi: 2006
Dergi Adı: NETHERLANDS JOURNAL OF MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.422-424
Hacettepe Üniversitesi Adresli: Evet

Özet

We report successful treatment of a refractory myelodysplastic syndrome-associated pyoderma gangrenosum with the combination of thalidomide and interferon-alpha 2a in a single patient. A non-healing wound developed on a 40-year-old woman's left thumb after minor trauma. Massive ulcerovegetative lesions developed after reconstruction surgery. Histopathological examination of the bone marrow and cytogenetic studies revealed an atypical myeloproliferative/myelodysplastic syndrome. The skin lesions resolved dramatically after two months of thalidomide and interferon-a2a combination therapy and the haematological status improved.