The effects of lyophilization on the stability of liposomes containing 5-FU

Glavas-Dodov, M; Fredro-Kumbaradzi, E; Goracinova, K; Simonoska, M; Calis, SEMA; Trajkovic-Jolevskaa, S; Hincal, AA

doi:10.1016/j.ijpharm.2004.07.045

The effects of lyophilization on the stability of liposomes containing 5-FU

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Glavas-Dodov M., Fredro-Kumbaradzi E., Goracinova K., Simonoska M., Calis S., Trajkovic-Jolevskaa S., ...More

INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol.291, pp.79-86, 2005 (SCI-Expanded)

Publication Type: Article / Article
Volume: 291
Publication Date: 2005
Doi Number: 10.1016/j.ijpharm.2004.07.045
Journal Name: INTERNATIONAL JOURNAL OF PHARMACEUTICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.79-86
Hacettepe University Affiliated: Yes

Abstract

Multilamellar liposomes containing 5-fluorouracil (5-FU) were prepared by modified lipid film hydration method and were lyophilized with or without saccharose as cryoprotectant. The effect of lyophilization on the stability of liposomes was evaluated by comparing the vesicle size, encapsulation efficiency and the drug release rate before and after lyophilization/rehydration.