The effects of lyophilization on the stability of liposomes containing 5-FU


Glavas-Dodov M., Fredro-Kumbaradzi E., Goracinova K., Simonoska M., Calis S. , Trajkovic-Jolevskaa S., ...Daha Fazla

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.291, ss.79-86, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 291
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.ijpharm.2004.07.045
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Sayfa Sayıları: ss.79-86

Özet

Multilamellar liposomes containing 5-fluorouracil (5-FU) were prepared by modified lipid film hydration method and were lyophilized with or without saccharose as cryoprotectant. The effect of lyophilization on the stability of liposomes was evaluated by comparing the vesicle size, encapsulation efficiency and the drug release rate before and after lyophilization/rehydration.