The effects of lyophilization on the stability of liposomes containing 5-FU


Glavas-Dodov M., Fredro-Kumbaradzi E., Goracinova K., Simonoska M., Calis S., Trajkovic-Jolevskaa S., ...More

INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol.291, pp.79-86, 2005 (SCI-Expanded) identifier identifier identifier

Abstract

Multilamellar liposomes containing 5-fluorouracil (5-FU) were prepared by modified lipid film hydration method and were lyophilized with or without saccharose as cryoprotectant. The effect of lyophilization on the stability of liposomes was evaluated by comparing the vesicle size, encapsulation efficiency and the drug release rate before and after lyophilization/rehydration.