The effects of lyophilization on the stability of liposomes containing 5-FU

Glavas-Dodov, M; Fredro-Kumbaradzi, E; Goracinova, K; Simonoska, M; Calis, SEMA; Trajkovic-Jolevskaa, S; Hincal, AA

doi:10.1016/j.ijpharm.2004.07.045

The effects of lyophilization on the stability of liposomes containing 5-FU

Atıf İçin Kopyala

Glavas-Dodov M., Fredro-Kumbaradzi E., Goracinova K., Simonoska M., Calis S., Trajkovic-Jolevskaa S., ...Daha Fazla

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.291, ss.79-86, 2005 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 291
Basım Tarihi: 2005
Doi Numarası: 10.1016/j.ijpharm.2004.07.045
Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.79-86
Hacettepe Üniversitesi Adresli: Evet

Özet

Multilamellar liposomes containing 5-fluorouracil (5-FU) were prepared by modified lipid film hydration method and were lyophilized with or without saccharose as cryoprotectant. The effect of lyophilization on the stability of liposomes was evaluated by comparing the vesicle size, encapsulation efficiency and the drug release rate before and after lyophilization/rehydration.