CHEMICAL PAPERS, cilt.66, sa.1, ss.54-60, 2012 (SCI-Expanded)
Boric acid forms meta-stable complexes with biomolecules like amino and hydroxy acids and stable complexes with the diol group containing carbohydrates, vitamins, and nucleotides, yielding mono-chelate (1 : 1 complex) or bis-chelate (1 : 2 complex) structures with negatively charged tetrahedral borate anions. Here we report water-soluble, bio-available mixed-ligand boron adducts for potential nutritional and/or pharmaceutical applications. The complexes were prepared by complete esterification of boric acid with a number of acyclic-and cyclic hydroxy-functionalized biomolecules employing sodium as the counter ion. Structural and thermal properties of the complexes were investigated using chemical analysis, B-11 NMR, FTIR, and TGA-DTA techniques. Complexes containing salicylic acid as one of the ligands displayed higher thermal and hydrolytic stabilities. (C) 2011 Institute of Chemistry, Slovak Academy of Sciences