Synthesis and structure of (7aRS)-4-chloro-6-(4-methyl­phen­yl)-6,7,7a,8-tetra­hydro-5H-indeno­[5,6-b]furan-5-one, a fused-ring system arising from a new variant of the IMDAV reaction

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Alekseeva K. A., Gurbanov A. V., Grigoriev M. S., Salakhova V. I., Akishina E. A., Al-Douh M. H., ...More

Acta Crystallographica Section E: Crystallographic Communications, vol.82, pp.212-216, 2026 (ESCI, Scopus)

• Publication Type: Article / Article
• Volume: 82
• Publication Date: 2026
• Doi Number: 10.1107/s2056989026000629
• Journal Name: Acta Crystallographica Section E: Crystallographic Communications
• Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
• Page Numbers: pp.212-216
• Keywords: crystal structure, furo[2,3-f]isoindole, IMDAV, isoindole, noncovalent interactions, structure
• Hacettepe University Affiliated: Yes

Abstract

The asymmetric unit of the title compound, C17H14ClNO2, contains two molecules, a and b, where the hydrobenzene and pyrrole rings are in screw-boat and half-chair conformations, respectively. In the crystal, C - H⋯O and C - H⋯Cl hydrogen bonds link the molecules into two-dimensional networks, enclosing R33(19), R22(18) and R22(14) ring motifs. Hirshfeld surface analysis revealed that the most important contributions to the crystal packing are from H⋯H (41.4 and 41.5% for molecules a and b, respectively), H⋯C/C⋯H (18.1 and 20.2%), H⋯O/O⋯H (16.0 and 13.4%) and H⋯Cl/Cl⋯H (13.4 and 11.9%) interactions.