Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus

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Gursoy I. D., BARUN S., Erdem R., KESKİN U., Kiziltas M., ATİLLA P., ...More

TURKISH NEUROSURGERY, vol.30, no.6, pp.871-884, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.5137/1019-5149.jtn.27023-19.3
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.871-884
  • Keywords: Status epilepticus, Electroconvulsive seizure, Ketamine, Dantrolene, Cognition, Rats, METHYL-D-ASPARTATE, CELL-DEATH, ENDOPLASMIC-RETICULUM, RECEPTOR HYPOFUNCTION, SYNAPTIC PLASTICITY, GABAERGIC NEURONS, MEMORY IMPAIRMENT, SELECTIVE LOSS, DENTATE GYRUS, KAINIC ACID
  • Hacettepe University Affiliated: Yes

Abstract

AIM: To evaluate the possible neuroprotective effects of ketamine and dantrolene on the hippocampal apoptosis and spatial learning in rats exposed to repeated electroconvulsive seizures (ECS) as a model of status epilepticus (SE).