Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus

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Gursoy I. D., BARUN S., Erdem R., KESKİN U., Kiziltas M., ATİLLA P., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.30, sa.6, ss.871-884, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5137/1019-5149.jtn.27023-19.3
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.871-884
  • Anahtar Kelimeler: Status epilepticus, Electroconvulsive seizure, Ketamine, Dantrolene, Cognition, Rats, METHYL-D-ASPARTATE, CELL-DEATH, ENDOPLASMIC-RETICULUM, RECEPTOR HYPOFUNCTION, SYNAPTIC PLASTICITY, GABAERGIC NEURONS, MEMORY IMPAIRMENT, SELECTIVE LOSS, DENTATE GYRUS, KAINIC ACID
  • Hacettepe Üniversitesi Adresli: Evet

Özet

AIM: To evaluate the possible neuroprotective effects of ketamine and dantrolene on the hippocampal apoptosis and spatial learning in rats exposed to repeated electroconvulsive seizures (ECS) as a model of status epilepticus (SE).