Could drug burden be associated with severe periodontitis in patients receiving haemodialysis?

YETER H. H., ERTEN Y., İŞLER S. Ç., Soysal F., Elbeg S., ÜNSAL F. B.

Journal of Renal Care, vol.45, no.4, pp.239-247, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1111/jorc.12299
  • Journal Name: Journal of Renal Care
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.239-247
  • Keywords: Calcium channel blockers, Haemodialysis, Periodontitis, Polystyrene sulphonic acid, β antagonist
  • Hacettepe University Affiliated: Yes


Background: Periodontitis increases the risk of cardiovascular disease in the general population by triggering systemic inflammation. Aim: To investigate the relationship between systemic inflammation and periodontitis, and clarify any association between severe periodontitis and the medications used by patients receiving haemodialysis. Design: A cross-sectional study. Participants: The study was undertaken with 56 patients receiving haemodialysis. Measurements: Demographic and laboratory data and prescribed drugs regularly used by patients were recorded from hospital records. During the dialysis session, a validated Xerostomia Inventory score was completed. A complete dental/periodontal examination was also undertaken on all patients by the same periodontist. Results: In the study population, stage I periodontitis was determined in 41%, stage II periodontitis in 17%, stage III periodontitis in 21%, and stage IV periodontitis in 21%. Male gender, hypertension, coronary artery disease, β antagonists, calcium channel blockers, sodium polystyrene sulphonate, teeth brushing less than twice a day and high sensitive C-reactive protein > 8 mg/l were significantly associated with severe periodontitis. Conclusion: Drugs, including β antagonists, calcium channel blockers, polystyrene sulphonate, co-morbid conditions and poor or insufficient oral care could facilitate an increase in the severity of periodontitis in patients receiving haemodialysis. Severe periodontitis also seems to be associated with cardiovascular disease and inflammation in patients with chronic renal disease.