STUDIES ON CONSTITUENTS WITH CYTOTOXIC AND CYTOSTATIC ACTIVITY OF 2 TURKISH MEDICINAL-PLANTS PHLOMIS-ARMENIACA AND SCUTELLARIA-SALVIIFOLIA


SARACOGLU I. , INOUE M., ÇALIŞ İ. , OGIHARA Y.

BIOLOGICAL & PHARMACEUTICAL BULLETIN, cilt.18, sa.10, ss.1396-1400, 1995 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Konu: 10
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1248/bpb.18.1396
  • Dergi Adı: BIOLOGICAL & PHARMACEUTICAL BULLETIN
  • Sayfa Sayıları: ss.1396-1400

Özet

Ten known glycosidic compounds, betulalbuside A (1), 8-hydroxylioaloyl,3-O-beta-D-glucopyranoside (2) (monoterpen glycosides), ipolamiide (3) (iridoid glycoside), acteoside (verbascoside) (4), leucosceptoside A (5), martynoside (6), forsythoside B (7), phlinoside B (8), phlinoside C (9), and teucrioside (10) (phenylpropanoid glycosides) mere isolated from methanolic extracts of Phlomis armeniaca and Scutellaria salviifolia (Labiatae). Structure elucidations were carried out using H-1-, C-13-NMR and FAB-MS spectra, as well as chemical evidence. The cytotoxic and cytostatic activities of isolated compounds were investigated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method. Among the glycosides obtained here, caffeic acid-containing phenylpropanoid (or phenethyl alcohol, or phenylethanoid) glycosides were found to show activity against several kinds of cancer cells. However, they didn't affect the growth and viability of primary-cultured rat hepatocytes. Study of the structure-activity relationship indicated that ortho-dihydroxy aromatic systems of phenylpropanoid glycosides are necessary for their cytotoxic and cytostatic activities.