Farnesylthiosalicylic acid-loaded lipid-polyethylene glycol-polymer hybrid nanoparticles for treatment of glioblastoma

KAFFASHI, MELİKE; Lule, SEVDA; PEHLIVAN, Sibel; SARISOZEN, Can; VURAL, İMRAN; KOSUCU, Husnu; Demir, Taner; Bugdayci, Kadir; Soylemezoglu, Figen; OGUZ, Kader; Mut, Melike

doi:10.1111/jphp.12740

Farnesylthiosalicylic acid-loaded lipid-polyethylene glycol-polymer hybrid nanoparticles for treatment of glioblastoma

KAFFASHI A., Lule S., PEHLIVAN S. B., SARISOZEN C., VURAL İ., KOSUCU H., ...More

JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.69, no.8, pp.1010-1021, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 69 Issue: 8
Publication Date: 2017
Doi Number: 10.1111/jphp.12740
Journal Name: JOURNAL OF PHARMACY AND PHARMACOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1010-1021
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

ObjectivesWe aimed to develop lipid-polyethylene glycol (PEG)-polymer hybrid nanoparticles, which have high affinity to tumour tissue with active ingredient, a new generation antineoplastic drug, farnesylthiosalicylic acid (FTA) for treatment of glioblastoma.