5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents


Ekinci A. S. , Moncol J., Krishna V. S. , Sriram D., Ozadali-Sari K.

JOURNAL OF RESEARCH IN PHARMACY, cilt.24, ss.30-37, 2020 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 24 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.35333/jrp.2020.110
  • Dergi Adı: JOURNAL OF RESEARCH IN PHARMACY
  • Sayfa Sayıları: ss.30-37

Özet

This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds (2a and 2c) were determined by the single-crystal X-ray diffraction study. Among the target compounds, 2-(4-ethoxypheny1)-5-methyl-3-(phenylamino)thiazolidin-4-one (2g) was promising with a minimum inhibitory concentration of 12.5 mu g/mL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity.