Loading of cancer drug resveratrol to pH-Sensitive, smart, alginate-chitosan hydrogels and investigation of controlled release kinetics

Nazli A. B., Acikel Y.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol.53, 2019 (SCI-Expanded) identifier identifier


In this study, alginate-chitosan(ALG-CTN) composite beads were synthesized by using the "drip technique" and by benefiting from the feature of forming the polyelectrolyte complex(PEC) by combining anionic alginate(ALG) and cationic chitosan(CTN). Characterization studies of synthesized ALG-CTN hydrogels were evaluated by the FTIR, TGA, SEM-EDS, and BET analyses. Resveratrol(RST) drug, which is used in cancer treatment, was loaded to synthesized ALG-CTN hybrid beads, and their encapsulation efficiency and loading capacity were calculated and compared with those of Ca-ALG beads. The swelling behaviors of Ca-ALG beads and ALG-CTN hybrid beads prepared at different mass ratios were investigated in different pH buffers. The release of RST was evaluated in vitro in buffer solutions at different pH, representing different parts of the gastrointestinal system, and the blood. The effects of the mass ratios of ALG and CTN in the composite structure to each other, the amount of RST and the ambient pH on cumulative RST release from ALG-CTN hybrid beads were investigated. The cumulative RST release percentages were compared with those of Ca-ALG beads. In order to determine the RST release mechanism from ALG-CTN hybrid beads, the compatibility of the release data at different pH values with the drug release kinetics models was investigated.