A clinically isolated syndrome: A challenging entity

Kurne A., Isikay I. C., Karlioguz K., KALYONCU U., AYDIN Ö. F., Calguneri M., ...More

JOURNAL OF NEUROLOGY, vol.255, no.11, pp.1625-1635, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 255 Issue: 11
  • Publication Date: 2008
  • Doi Number: 10.1007/s00415-008-0882-y
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1625-1635
  • Hacettepe University Affiliated: Yes


Acute isolated neurological syndromes, such as optic neuropathy or transverse myelopathy, may cause diagnostic problems since they can be the first presentations of a number of diseases such as multiple sclerosis (MS) and collageneous tissue disorders. In the present study, particular systemic lupus erythematosus (SLE) and primary Sjogren syndrome (pSS) patients, who were followed up with the initial diagnosis of possible MS with no evidence of collagen tissue disorders for several years, are described. Five patients with the final diagnosis of SLE and five pSS patients are evaluated with their neurologic, systemic and radiologic findings.