Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study

Sinnollareddy, Mahipal; Roberts, Jason; Lipman, Jeffrey; AKOVA, MURAT; Bassetti, Matteo; De Waele, Jan; Kaukonen, Kirsi-Maija; Koulenti, Despoina; Martin, Claude; Montravers, Philippe; Rello, Jordi; Rhodes, Andrew; Starr, Therese; Wallis, Steven; Dimopoulos, George

doi:10.1186/s13054-015-0758-3

Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study

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Sinnollareddy M. G., Roberts J. A., Lipman J., AKOVA M., Bassetti M., De Waele J. J., ...More

CRITICAL CARE, vol.19, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 19
Publication Date: 2015
Doi Number: 10.1186/s13054-015-0758-3
Journal Name: CRITICAL CARE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Hacettepe University Affiliated: Yes

Abstract

Introduction: The objective of the study was to describe the pharmacokinetics (PK) of fluconazole, anidulafungin, and caspofungin in critically ill patients and to compare with previously published data. We also sought to determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets in this cohort of intensive care unit patients.