Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study


Sinnollareddy M. G. , Roberts J. A. , Lipman J., AKOVA M. , Bassetti M., De Waele J. J. , ...More

CRITICAL CARE, vol.19, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19
  • Publication Date: 2015
  • Doi Number: 10.1186/s13054-015-0758-3
  • Title of Journal : CRITICAL CARE

Abstract

Introduction: The objective of the study was to describe the pharmacokinetics (PK) of fluconazole, anidulafungin, and caspofungin in critically ill patients and to compare with previously published data. We also sought to determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets in this cohort of intensive care unit patients.