Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study


Sinnollareddy M. G. , Roberts J. A. , Lipman J., AKOVA M. , Bassetti M., De Waele J. J. , ...Daha Fazla

CRITICAL CARE, cilt.19, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1186/s13054-015-0758-3
  • Dergi Adı: CRITICAL CARE

Özet

Introduction: The objective of the study was to describe the pharmacokinetics (PK) of fluconazole, anidulafungin, and caspofungin in critically ill patients and to compare with previously published data. We also sought to determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets in this cohort of intensive care unit patients.