Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages

Schieck, Maximilian; Schouten, Jan; Michel, Sven; Suttner, Kathrin; Toncheva, Antoaneta; Gaertner, Vincent; Illig, Thomas; Lipinski, Simone; Franke, Andre; Klintschar, Michael; Kalayci, Omer; Sahiner, ÜMİT; BİRBEN, ESRA; Melen, Erik; Pershagen, Goeran; Freidin, Maxim; Ogorodova, Ludmila; Granell, Raquel; Henderson, John; Brunekreef, Bert; Smit, Henriette; Vogelberg, Christian; von Berg, Andrea; Bufe, Albrecht; Heinzmann, Andrea; Laub, Otto; Rietschel, Ernst; Simma, Burkhard; Genuneit, Jon; Jonigk, Danny; Postma, Dirkje; Koppelman, Gerard; Vonk, Judith; Timens, Wim; Boezen, H.; Kabesch, Michael

doi:10.1016/j.jaci.2015.12.1305

Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages

Atıf İçin Kopyala

Schieck M., Schouten J. P., Michel S., Suttner K., Toncheva A. A., Gaertner V. D., ...Daha Fazla

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.138, sa.2, ss.421-431, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 138 Sayı: 2
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.jaci.2015.12.1305
Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.421-431
Anahtar Kelimeler: Asthma, genetic association, DMRT1, interaction, rs3812523, sex, single nucleotide polymorphism, GENOME, ASSOCIATION, VARIANTS, HEALTH, RISK
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Asthma is a disease affecting more boys than girls in childhood and more women than men in adulthood. The mechanisms behind these sex-specific differences are not yet understood.