Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages

Schieck, Maximilian; Schouten, Jan; Michel, Sven; Suttner, Kathrin; Toncheva, Antoaneta; Gaertner, Vincent; Illig, Thomas; Lipinski, Simone; Franke, Andre; Klintschar, Michael; Kalayci, Omer; Sahiner, ÜMİT; BİRBEN, ESRA; Melen, Erik; Pershagen, Goeran; Freidin, Maxim; Ogorodova, Ludmila; Granell, Raquel; Henderson, John; Brunekreef, Bert; Smit, Henriette; Vogelberg, Christian; von Berg, Andrea; Bufe, Albrecht; Heinzmann, Andrea; Laub, Otto; Rietschel, Ernst; Simma, Burkhard; Genuneit, Jon; Jonigk, Danny; Postma, Dirkje; Koppelman, Gerard; Vonk, Judith; Timens, Wim; Boezen, H.; Kabesch, Michael

doi:10.1016/j.jaci.2015.12.1305

Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages

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Schieck M., Schouten J. P., Michel S., Suttner K., Toncheva A. A., Gaertner V. D., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.138, no.2, pp.421-431, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 138 Issue: 2
Publication Date: 2016
Doi Number: 10.1016/j.jaci.2015.12.1305
Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.421-431
Keywords: Asthma, genetic association, DMRT1, interaction, rs3812523, sex, single nucleotide polymorphism, GENOME, ASSOCIATION, VARIANTS, HEALTH, RISK
Hacettepe University Affiliated: Yes

Abstract

Background: Asthma is a disease affecting more boys than girls in childhood and more women than men in adulthood. The mechanisms behind these sex-specific differences are not yet understood.