In Silico Cross Seeding of A beta and Amylin Fibril-like Oligomers
ACS CHEMICAL NEUROSCIENCE, cilt.4, sa.11, ss.1488-1500, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4 Sayı: 11
- Basım Tarihi: 2013
- Doi Numarası: 10.1021/cn400141x
- Dergi Adı: ACS CHEMICAL NEUROSCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1488-1500
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Hacettepe Üniversitesi Adresli: Evet
Özet
Recent epidemiological data have shown that patients suffering from Type 2 Diabetes Mellitus have an increased risk to develop Alzheimer's disease and vice versa. A possible explanation is the cross-sequence interaction between A beta and amylin. Because the resulting amyloid oligomers are difficult to probe in experiments, we investigate stability and conformational changes of A beta amylin heteroassemblies through molecular dynamics simulations. We find that A beta is a good template for the growth of amylin and vice versa. We see water molecules permeate the beta-strand-turn-beta-strand motif pore of the oligomers, supporting a commonly accepted mechanism for toxicity of A beta-rich amyloid oligomers. Aiming for a better understanding of the physical mechanisms of cross-seeding and cell toxicity of amylin and A beta aggregates, our simulations also allow us to identify targets for the rational design of inhibitors against toxic fibril-like oligomers of A beta and amylin oligomers.