Antithrombin III attenuates pulmonary tissue injury caused by mesenteric. ischemia-reperfusion


Aytekin F., Tekin K., Kabay B., Erdem E., Guney Y., Firat P., ...Daha Fazla

AMERICAN JOURNAL OF SURGERY, cilt.189, sa.2, ss.161-166, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 189 Konu: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.amjsurg.2004.11.003
  • Dergi Adı: AMERICAN JOURNAL OF SURGERY
  • Sayfa Sayıları: ss.161-166

Özet

Background: Mesenteric ischemia-reperfusion (I/R) is a well-known event causing both local and remote organ injuries, including the lungs. Recently, several studies indicated that activated leukocyte-endothelial cell interactions play an important role in the mechanisms of these injuries. As a natural inhibitor of serine proteases, antithrombin was shown previously to attenuate the tissue damage after local I/R in several organ systems. Here, we examined the effects of antithrombin on pulmonary injury after mesenteric I/R.