Antithrombin III attenuates pulmonary tissue injury caused by mesenteric. ischemia-reperfusion
AMERICAN JOURNAL OF SURGERY, vol.189, no.2, pp.161-166, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 189 Issue: 2
- Publication Date: 2005
- Doi Number: 10.1016/j.amjsurg.2004.11.003
- Journal Name: AMERICAN JOURNAL OF SURGERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.161-166
- Hacettepe University Affiliated: No
Abstract
Background: Mesenteric ischemia-reperfusion (I/R) is a well-known event causing both local and remote organ injuries, including the lungs. Recently, several studies indicated that activated leukocyte-endothelial cell interactions play an important role in the mechanisms of these injuries. As a natural inhibitor of serine proteases, antithrombin was shown previously to attenuate the tissue damage after local I/R in several organ systems. Here, we examined the effects of antithrombin on pulmonary injury after mesenteric I/R.