Antithrombin III attenuates pulmonary tissue injury caused by mesenteric. ischemia-reperfusion

Aytekin F., Tekin K., Kabay B., Erdem E., Guney Y., Firat P., ...More

AMERICAN JOURNAL OF SURGERY, vol.189, no.2, pp.161-166, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 189 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.amjsurg.2004.11.003
  • Journal Name: AMERICAN JOURNAL OF SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.161-166
  • Hacettepe University Affiliated: No

Abstract

Background: Mesenteric ischemia-reperfusion (I/R) is a well-known event causing both local and remote organ injuries, including the lungs. Recently, several studies indicated that activated leukocyte-endothelial cell interactions play an important role in the mechanisms of these injuries. As a natural inhibitor of serine proteases, antithrombin was shown previously to attenuate the tissue damage after local I/R in several organ systems. Here, we examined the effects of antithrombin on pulmonary injury after mesenteric I/R.