Association Between Platelet to Lymphocyte Ratio and Saphenous Vein Graft Disease

Yayla C., Canpolat U., Akyel A., Yayla K. G., Yilmaz S., Acikgoz S. K., ...More

ANGIOLOGY, vol.67, no.2, pp.133-138, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1177/0003319715578258
  • Journal Name: ANGIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.133-138
  • Keywords: platelet to lymphocyte ratio, inflammation, saphenous vein graft disease, ELEVATION MYOCARDIAL-INFARCTION, CLINICAL-OUTCOMES, PROGNOSTIC MARKER, CORONARY, INFLAMMATION, PATHOGENESIS, COUNT, VOLUME
  • Hacettepe University Affiliated: Yes


Atherosclerosis plays an important role in saphenous vein graft disease (SVGD). Previous trials showed that inflammatory blood cells play a role in this process. The platelet to lymphocyte ratio (PLR) has been proposed as a novel predictor for cardiovascular risk and indicator of atherosclerosis. The aim of this study was to assess the relationship between SVGD and PLR. A total of 220 patients with SVG were enrolled (n = 87 with SVGD and n = 133 with patent SVG). A 50% stenosis within the SVG was defined as clinically significant. Median PLR (P < .001) and mean platelet volume (MPV; P = .043) were significantly higher in patients with SVGD. Also, PLR showed significantly positive correlation with age of SVG (P < .05). Median age of SVGs was also higher in the SVGD group (P = .025). In multivariate logistic regression analyses, the PLR and MPV were independent predictors of SVGD. Using a cutoff level of 106.3, the PLR predicted SVGD with a sensitivity of 87.4% and a specificity of 80.3%. To the best of our knowledge, this study showed, for the first time, that PLR was independently associated with SVGD. Both PLR and MPV might predict SVGD.