Natural cutaneous anthrax infection, but not vaccination, induces a CD4(+) T cell response involving diverse cytokines

Ingram, Rebecca; Ascough, Stephanie; Reynolds, Catherine; Metan, GÖKHAN; DOĞANAY, MEHMET; Baillie, Les; Williamson, Diane; Robinson, John; Maillere, Bernard; Boyton, Rosemary; Altmann, Daniel

doi:10.1186/s13578-015-0011-4

Natural cutaneous anthrax infection, but not vaccination, induces a CD4(+) T cell response involving diverse cytokines

Atıf İçin Kopyala

Ingram R. J., Ascough S., Reynolds C. J., Metan G., DOĞANAY M., Baillie L., ...Daha Fazla

CELL AND BIOSCIENCE, cilt.5, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 5
Basım Tarihi: 2015
Doi Numarası: 10.1186/s13578-015-0011-4
Dergi Adı: CELL AND BIOSCIENCE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Whilst there have been a number of insights into the subsets of CD4(+) T cells induced by pathogenic Bacillus anthracis infections in animal models, how these findings relate to responses generated in naturally infected and vaccinated humans has yet to be fully established. We describe the cytokine profile produced in response to T cell stimulation with a previously defined immunodominant antigen of anthrax, lethal factor (LF), domain IV, in cohorts of individuals with a history of cutaneous anthrax, compared with vaccinees receiving the U.K. licenced Anthrax Vaccine Precipitated (AVP) vaccine.