PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations

Hatano Y., Sato K., Elibol B., Yoshino H., Yamamura Y., Bonifati V., ...Daha Fazla

NEUROLOGY, cilt.63, sa.8, ss.1482-1485, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 8
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1212/01.wnl.0000142258.29304.fe
  • Dergi Adı: NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1482-1485
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod) score of 9.88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism.