PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations

Hatano, Y; Sato, K; Elibol, B; Yoshino, H; Yamamura, FATMA; Bonifati, V; Shinotoh, H; Asahina, M; Kobayashi, S; Ng, AR; Rosales, RL; Hassin-Baer, S; Shinar, Y; Lu, CS; Chang, HC; Wu-Chou, YH; Atac, FB; Kobayashi, T; Toda, T; Mizuno, Y; Hattori, N

doi:10.1212/01.wnl.0000142258.29304.fe

PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations

Hatano Y., Sato K., Elibol B., Yoshino H., Yamamura Y., Bonifati V., ...More

NEUROLOGY, vol.63, no.8, pp.1482-1485, 2004 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 63 Issue: 8
Publication Date: 2004
Doi Number: 10.1212/01.wnl.0000142258.29304.fe
Journal Name: NEUROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1482-1485
Hacettepe University Affiliated: Yes

Abstract

The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod) score of 9.88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism.