Short-Hairpin RNA Silencing of Endogenous Fibroblast Growth Factor 2 in Rat Hippocampus Increases Anxiety Behavior

EREN KOÇAK E. , Turner C. A. , Watson S. J. , Akil H.

BIOLOGICAL PSYCHIATRY, vol.69, no.6, pp.534-540, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 6
  • Publication Date: 2011
  • Doi Number: 10.1016/j.biopsych.2010.11.020
  • Title of Journal : BIOLOGICAL PSYCHIATRY
  • Page Numbers: pp.534-540


Background: The fibroblast growth factor system has been implicated in the pathophysiology of mood disorders in humans and in affective behavior in animal models. However, the studies have been either correlative or involved exogenous administration of fibroblast growth factor 2 (FGF2). None of them have directly linked endogenous FGF2 to changes in emotional responses. Therefore, we began a series of studies to knockdown FGF2 by RNA interference to examine the role of brain FGF2 in emotional responsiveness.