Short-Hairpin RNA Silencing of Endogenous Fibroblast Growth Factor 2 in Rat Hippocampus Increases Anxiety Behavior

EREN KOÇAK, EMİNE; Turner, Cortney; Watson, Stanley; Akil, Huda

doi:10.1016/j.biopsych.2010.11.020

Short-Hairpin RNA Silencing of Endogenous Fibroblast Growth Factor 2 in Rat Hippocampus Increases Anxiety Behavior

EREN KOÇAK E., Turner C. A., Watson S. J., Akil H.

BIOLOGICAL PSYCHIATRY, cilt.69, sa.6, ss.534-540, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 69 Sayı: 6
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.biopsych.2010.11.020
Dergi Adı: BIOLOGICAL PSYCHIATRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.534-540
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: The fibroblast growth factor system has been implicated in the pathophysiology of mood disorders in humans and in affective behavior in animal models. However, the studies have been either correlative or involved exogenous administration of fibroblast growth factor 2 (FGF2). None of them have directly linked endogenous FGF2 to changes in emotional responses. Therefore, we began a series of studies to knockdown FGF2 by RNA interference to examine the role of brain FGF2 in emotional responsiveness.