Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents

Turan-Zitounl G., Kaplancikli Z. A., Ozdemir A., Chevallet P., Kandilci H. B., Gumusel B.

ARCHIV DER PHARMAZIE, vol.340, no.11, pp.586-590, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 340 Issue: 11
  • Publication Date: 2007
  • Doi Number: 10.1002/ardp.200700134
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.586-590
  • Hacettepe University Affiliated: No

Abstract

The reaction of acetic or propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the 1,2,4-triazoles by alkali cyclization. The 4-aryl/allcyl-5-(1phenoxyethyl)-3-[N-(substituted)acetamido]thio-4H-1,2,4-triazole derivatives were synthesized by reactinc the triazoles with 2-chloro-N-(substituted)acetamide. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data and elemental analysis. In the pharmacological studies, anti-inflammatory activities of these compounds have been screened and significant activities were observed.