Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents


Turan-Zitounl G., Kaplancikli Z. A. , Ozdemir A., Chevallet P., Kandilci H. B. , Gumusel B.

ARCHIV DER PHARMAZIE, cilt.340, ss.586-590, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 340 Konu: 11
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/ardp.200700134
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Sayfa Sayıları: ss.586-590

Özet

The reaction of acetic or propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the 1,2,4-triazoles by alkali cyclization. The 4-aryl/allcyl-5-(1phenoxyethyl)-3-[N-(substituted)acetamido]thio-4H-1,2,4-triazole derivatives were synthesized by reactinc the triazoles with 2-chloro-N-(substituted)acetamide. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data and elemental analysis. In the pharmacological studies, anti-inflammatory activities of these compounds have been screened and significant activities were observed.